Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester
نویسندگان
چکیده
منابع مشابه
Screening of commercial enzymes for the enantioselective hydrolysis of R,S-naproxen ester
This study focused on the identification of suitable lipase or esterase activity for enantiomeric resolution of (R,S)-naproxen. For an economically viable reaction the enantiomeric ratio (E) should preferably be >100, while maximising the conversion will reduce the mass of material that requires racemisation and recycling. Hence the aim was to find an enzyme that yields (S)-naproxen with an ena...
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Bacteria were enriched from soil samples with succinate as a carbon source and racemic naproxen nitrile [2-(6-methoxy-2-naphthyl)propionitrile] as sole source of nitrogen. Since naproxen nitrile was only poorly soluble in water media amended with different water-immiscible organic phases were used for the enrichments. With pristane (2,6,10,14-tetramethylpentadecane) as the organic phase two bac...
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The bacterial strain Rhodococcus butanica (ATCC 21197), which exhibits nitrilase and nitrile hydratase/amidase activities, catalyses the enantioselective hydrolysis of racemic naproxen nitrile (R/S)-1 to furnish a moderate enantiomeric excess of (S)-naproxen (S)-3. Racemic naproxen amide (R/S)-2 is not a good substrate for this strain. Resting cells of the newly selected bacterial strain Rhodoc...
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Kinetics of the neutral hydrolysis of 4-nitrophenyl chloroacetate was investigated in water and in the presence of 1 mol % of ethanol, propanol, and -butyl n alcohol without sonication and under ultrasound at 25 kHz. Similarly, the kinetics of the acid-catalysed hydrolysis of -propyl n acetate in ethanol–water binary solutions was investigated without sonication and under ultrasound at 22 kHz. ...
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Cultured rabbit aortic smooth muscle cells were converted to foam cells by exposure to sonicated lipid droplets of defined composition using an inverted culture technique. Uptake of the lipid droplets by the cells was shown to be dependent on the time of exposure to the droplets and on the mass of droplets presented to the cells. A comparison of the hydrolysis of triolein and cholesteryl oleate...
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ژورنال
عنوان ژورنال: Catalysts
سال: 2019
ISSN: 2073-4344
DOI: 10.3390/catal9030232